Peroxisome proliferator activated receptor-γ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus

Sarfaraz Hasni; Yenealem Temesgen-Oyelakin; Michael Davis; Jun Chu; Elaine Poncio; Mohammad Naqi; Sarthak Gupta; Xinghao Wang; Christopher Oliveira; Dillon Claybaugh; Amit Dey; Shajia Lu; Philip Carlucci; Monica Purmalek; Zerai G Manna; Yinghui Shi; Isabel Ochoa-Navas; Jinguo Chen; Amrita Mukherjee; Kyu Lee Han; Foo Cheung; Galina Koroleva; Yasmine Belkaid; John S Tsang; Richard Apps; Donald E Thomas; Theo Heller; Massimo Gadina; Martin P Playford; Xiaobai Li; Nehal N Mehta; Mariana J Kaplan

doi:10.1136/ard-2022-222658

Research ArticleSystemic lupus erythematosus

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Peroxisome proliferator activated receptor-γ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus

Sarfaraz Hasni, Yenealem Temesgen-Oyelakin, Michael Davis, Jun Chu, Elaine Poncio, Mohammad Naqi, Sarthak Gupta, Xinghao Wang, Christopher Oliveira, Dillon Claybaugh, Amit Dey, Shajia Lu, Philip Carlucci, Monica Purmalek, Zerai G Manna, Yinghui Shi, Isabel Ochoa-Navas, Jinguo Chen, Amrita Mukherjee, Kyu Lee Han, Foo Cheung, Galina Koroleva, Yasmine Belkaid, John S Tsang, Richard Apps, Donald E Thomas, Theo Heller, Massimo Gadina, Martin P Playford, Xiaobai Li, Nehal N Mehta and Mariana J Kaplan

Annals of the Rheumatic Diseases August 2022, annrheumdis-2022-222658; DOI: https://doi.org/10.1136/ard-2022-222658

Sarfaraz Hasni

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Yenealem Temesgen-Oyelakin

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Michael Davis

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Jun Chu

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Elaine Poncio

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Mohammad Naqi

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Sarthak Gupta

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Xinghao Wang

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Christopher Oliveira

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Dillon Claybaugh

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Amit Dey

3 Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

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Shajia Lu

4 Translational Immunology Section, NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA

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Philip Carlucci

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Monica Purmalek

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Zerai G Manna

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Yinghui Shi

5 Office of the Clinical Director, NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA

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Isabel Ochoa-Navas

1 Lupus Clinical Trials Unit, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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Jinguo Chen

6 National Institutes of Health, Bethesda, Maryland, USA

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Amrita Mukherjee

6 National Institutes of Health, Bethesda, Maryland, USA

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Kyu Lee Han

6 National Institutes of Health, Bethesda, Maryland, USA

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Foo Cheung

6 National Institutes of Health, Bethesda, Maryland, USA

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Galina Koroleva

6 National Institutes of Health, Bethesda, Maryland, USA

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Yasmine Belkaid

7 Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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John S Tsang

8 Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, National Institutes of Health, Bethesda, Maryland, USA

9 NIH Center for Human Immunology, National Institutes of Health, Bethesda, Maryland, USA

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Richard Apps

6 National Institutes of Health, Bethesda, Maryland, USA

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Donald E Thomas

10 Arthritis and Pain Associates of PG County, Greenbelt, Maryland, USA

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Theo Heller

11 NIDDK, National Institutes of Health, Bethesda, Maryland, USA

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Massimo Gadina

12 NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Martin P Playford

13 National Heart Lung and Blood Institute, Bethesda, Maryland, USA

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Xiaobai Li

14 Biostatistics and Clinical Epidemiology Service, National Institutes of Health Clinical Center, Bethesda, Maryland, USA

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Nehal N Mehta

6 National Institutes of Health, Bethesda, Maryland, USA

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Mariana J Kaplan

2 Systemic Autoimmunity Branch/NIAMS, National Institutes of Health, Bethesda, Maryland, USA

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Article Information

annrheumdis-2022-222658

DOI

https://doi.org/10.1136/ard-2022-222658

Published By

BMJ Publishing Group Ltd

Print ISSN

0003-4967

Online ISSN

1468-2060

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Funding

National Institute of Allergy and Infectious Diseases
Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health
ZIAAR041199

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Peroxisome proliferator activated receptor-γ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus