PT  - JOURNAL ARTICLE
AU  - Vance, Carol Grace T.
AU  - Rakel, Barbara A.
AU  - Blodgett, Nicole P.
AU  - DeSantana, Josimari Melo
AU  - Amendola, Annunziato
AU  - Zimmerman, Miriam Bridget
AU  - Walsh, Deirdre M.
AU  - Sluka, Kathleen A.
TI  - Effects of Transcutaneous Electrical Nerve Stimulation on Pain, Pain Sensitivity, and Function in People With Knee Osteoarthritis: A Randomized Controlled Trial
AID  - 10.demo/ptj.20110183
DP  - 2012 Jul 01
TA  - Demo Journal of Physical Therapy
PG  - 898--910
VI  - 92
IP  - 7
4099  - http://demo.highwire.org/content/92/7/898.short
4100  - http://demo.highwire.org/content/92/7/898.full
AB  - Background Transcutaneous electrical nerve stimulation (TENS) is commonly used for the management of pain; however, its effects on several pain and function measures are unclear.Objective The purpose of this study was to determine the effects of high-frequency TENS (HF-TENS) and low-frequency TENS (LF-TENS) on several outcome measures (pain at rest, movement-evoked pain, and pain sensitivity) in people with knee osteoarthritis.Design The study was a double-blind, randomized clinical trial.Setting The setting was a tertiary care center.Participants Seventy-five participants with knee osteoarthritis (29 men and 46 women; 31–94 years of age) were assessed.Intervention Participants were randomly assigned to receive HF-TENS (100 Hz) (n=25), LF-TENS (4 Hz) (n=25), or placebo TENS (n=25) (pulse duration=100 microseconds; intensity=10% below motor threshold).Measurements The following measures were assessed before and after a single TENS treatment: cutaneous mechanical pain threshold, pressure pain threshold (PPT), heat pain threshold, heat temporal summation, Timed “Up & Go” Test (TUG), and pain intensity at rest and during the TUG. A linear mixed-model analysis of variance was used to compare differences before and after TENS and among groups (HF-TENS, LF-TENS, and placebo TENS).Results Compared with placebo TENS, HF-TENS and LF-TENS increased PPT at the knee; HF-TENS also increased PPT over the tibialis anterior muscle. There was no effect on the cutaneous mechanical pain threshold, heat pain threshold, or heat temporal summation. Pain at rest and during the TUG was significantly reduced by HF-TENS, LF-TENS, and placebo TENS.Limitations This study tested only a single TENS treatment.Conclusions Both HF-TENS and LF-TENS increased PPT in people with knee osteoarthritis; placebo TENS had no significant effect on PPT. Cutaneous pain measures were unaffected by TENS. Subjective pain ratings at rest and during movement were similarly reduced by active TENS and placebo TENS, suggesting a strong placebo component of the effect of TENS.